JOHN DICK’S  LABORATORY

Research Areas

Dr. Dick’s team investigates the biology of both hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs).

We are interested in understanding human hematopoiesis and leukemogenesis via unique human tissue based models and identifying genes, proteins, or epigenetic factors that are critical for these progressions.

We are also undertaking pre clinical studies of therapeutics to determine whether therapies are targeting cancer stem cells. We are also exploring potential biomarkers that may stratify leukemia patients genetically to provide the framework for personalized medicine.

Current projects include the following:

· Characterization of the role of leukemic stem cells in human leukemogenesis

· Molecular and cellular characterization of early human hematopoietic lineage determination

· Development of highly active anti-leukemia stem Cell therapy (HALT)

· Determinants of stemness and genetic diversity in leukemia